Raith Rovers can move a point ahead of neighbours Dunfermline Athletic at the top should they defeat Division One's other Fife outfit, Cowdenbeath.But the Kirkcaldy side are without the suspended Stephen Simmons and Dougie Hill, as well as the injured pair of Laurie Ellis and Iain Williamson.
Relegation-threatened Cowdenbeath are looking to move up into eighth place.
But they will again be without Joe Mbu, John Armstrong, Bob Malcolm and Colin Cameron through injury for the derby.
Raith Rovers manager John McGlynn: "I went to watch Cowdenbeath on Tuesday night against Ross County and they put on a very committed display in fairly horrific weather conditions.
"They battled for their win then and they will battle for everything here as they need the three points just as much as we do.
"Jimmy Nicholl has done a terrific job with his team and they will be very hard but very respected opponents."
Cowdenbeath manager Jimmy Nicholl: "This should be a cracking game and one where the team lower in the table may be looking to sit in, keep things tight and look for a point, but we are not aiming to do that."
"We will go and have a go like we did that last time we were there and were unlucky to go down 2-1.
"We defended stoutly against Ross County in midweek and we will need to defend stoutly at times in this game."
Source: BBC Sport
Source: BBC Sport